NATURE Article: Hydroxamic acid pre-adsorption raises the efficiency of cosensitized solar cells

2022-11-04

Dye-sensitized solar cells (DSCs) convert light into electricity by using photosensitizers adsorbed on the surface of nanocrystalline mesoporous titanium dioxide (TiO2) films along with electrolytes or solid charge-transport materials. They possess many features including transparency, multicolour and low-cost fabrication, and are being deployed in glass facades, skylights and greenhouses. Recent development of sensitizers, redox mediators?and device structures?has improved the performance of DS

Nature Communications paper: A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

2022-07-22

The success of glucagon-like peptide-1 (GLP-1) receptor agonists to treat type 2 diabetes (T2D) and obesity has sparked considerable efforts to develop next-generation co-agonists that are more effective. We conducted a randomised, placebo-controlled phase 1b study (ClinicalTrials.gov: NCT04466904) to evaluate the safety and efficacy of IBI362 (LY3305677), a GLP-1 and glucagon receptor dual agonist, in Chinese patients with T2D.

Science Paper: Ly6Chi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology

2022-07-18

Gammaherpesviruses (γHVs) coevolved with their hosts in a manner that allows for the lifelong persistence of these viruses in immunocompetent individuals. The presence of latent γHVs in host organisms has been shown to shape adaptive immunity, and here, Maquet et al.

Science Paper: FOXP3 exon 2 controls Treg stability and autoimmunity

2022-07-05

Human FOXP3 encodes two major isoforms regulated by alternative splicing: a full-length isoform and an isoform lacking exon 2 (FOXP3 ΔE2). How these isoforms differ in regulating Treg function is not well understood.

SCIENCE IMMUNOLOGY Artical: Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

2021-11-25

Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes via sulfated motifs that can recruit specific proteins. 3-O-sulfation of HS/heparin is crucial for anticoagulant activity, but despite emerging evidence for roles in many other functions, a lack of tools for deciphering structure-function relationships has hampered advances.

NATURE REVIEWS CARDIOLOGY Comment: Yoga for the prevention of cardiovascular disease

2020-02-15

Dorairaj Prabhakaran and Ambalam M.Chandrasekaran